Structure–Activity Relationships of Quinoxaline-Based 5-HT(3)A and 5-HT(3)AB Receptor-Selective Ligands

Until recently, discriminating between homomeric 5-HT(3)A and heteromeric 5-HT(3)AB receptors was only possible with ligands that bind in the receptor pore. This study describes the first series of ligands that can discriminate between these receptor types at the level of the orthosteric binding sit...

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Main Authors: Thompson, Andrew J, Verheij, Mark H P, van Muijlwijk-Koezen, Jacqueline E, Lummis, Sarah C R, Leurs, Rob, de Esch, Iwan J P
Formato: Artigo
Idioma:Inglês
Publicado: WILEY-VCH Verlag 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4063337/
https://ncbi.nlm.nih.gov/pubmed/23640722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201300032
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