5-Hydroxymethylcytosine is an essential intermediate of active DNA demethylation processes in primary human monocytes

BACKGROUND: Cytosine methylation is a frequent epigenetic modification restricting the activity of gene regulatory elements. Whereas DNA methylation patterns are generally inherited during replication, both embryonic and somatic differentiation processes require the removal of cytosine methylation a...

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Autors principals: Klug, Maja, Schmidhofer, Sandra, Gebhard, Claudia, Andreesen, Reinhard, Rehli, Michael
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2013
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4053946/
https://ncbi.nlm.nih.gov/pubmed/23705593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2013-14-5-r46
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