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Germline DNA Demethylation Dynamics and Imprint Erasure through 5-hydroxymethylcytosine
Mouse primordial germ cells (PGC) undergo sequential epigenetic changes and genome-wide DNA demethylation to reset the epigenome for totipotency. Here, we demonstrate that erasure of CpG methylation (5mC) in PGCs occurs via conversion to 5-hydroxymethylcytosine (5hmC), driven by high levels of TET1...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3847602/ https://ncbi.nlm.nih.gov/pubmed/23223451 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1229277 |
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