PRMT5 Protects Genomic Integrity during Global DNA Demethylation in Primordial Germ Cells and Preimplantation Embryos

Primordial germ cells (PGCs) and preimplantation embryos undergo epigenetic reprogramming, which includes comprehensive DNA demethylation. We found that PRMT5, an arginine methyltransferase, translocates from the cytoplasm to the nucleus during this process. Here we show that conditional loss of PRM...

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Detaylı Bibliyografya
Yayımlandı:Mol Cell
Asıl Yazarlar: Kim, Shinseog, Günesdogan, Ufuk, Zylicz, Jan J., Hackett, Jamie A., Cougot, Delphine, Bao, Siqin, Lee, Caroline, Dietmann, Sabine, Allen, George E., Sengupta, Roopsha, Surani, M. Azim
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Cell Press 2014
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4250265/
https://ncbi.nlm.nih.gov/pubmed/25457166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.10.003
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