PRMT5 Protects Genomic Integrity during Global DNA Demethylation in Primordial Germ Cells and Preimplantation Embryos

Primordial germ cells (PGCs) and preimplantation embryos undergo epigenetic reprogramming, which includes comprehensive DNA demethylation. We found that PRMT5, an arginine methyltransferase, translocates from the cytoplasm to the nucleus during this process. Here we show that conditional loss of PRM...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Cell
Prif Awduron: Kim, Shinseog, Günesdogan, Ufuk, Zylicz, Jan J., Hackett, Jamie A., Cougot, Delphine, Bao, Siqin, Lee, Caroline, Dietmann, Sabine, Allen, George E., Sengupta, Roopsha, Surani, M. Azim
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cell Press 2014
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4250265/
https://ncbi.nlm.nih.gov/pubmed/25457166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.10.003
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