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PRMT5 Protects Genomic Integrity during Global DNA Demethylation in Primordial Germ Cells and Preimplantation Embryos

Primordial germ cells (PGCs) and preimplantation embryos undergo epigenetic reprogramming, which includes comprehensive DNA demethylation. We found that PRMT5, an arginine methyltransferase, translocates from the cytoplasm to the nucleus during this process. Here we show that conditional loss of PRM...

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Библиографические подробности
Опубликовано в: :Mol Cell
Главные авторы: Kim, Shinseog, Günesdogan, Ufuk, Zylicz, Jan J., Hackett, Jamie A., Cougot, Delphine, Bao, Siqin, Lee, Caroline, Dietmann, Sabine, Allen, George E., Sengupta, Roopsha, Surani, M. Azim
Формат: Artigo
Язык:Inglês
Опубликовано: Cell Press 2014
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4250265/
https://ncbi.nlm.nih.gov/pubmed/25457166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.10.003
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