PRMT5 Protects Genomic Integrity during Global DNA Demethylation in Primordial Germ Cells and Preimplantation Embryos

Primordial germ cells (PGCs) and preimplantation embryos undergo epigenetic reprogramming, which includes comprehensive DNA demethylation. We found that PRMT5, an arginine methyltransferase, translocates from the cytoplasm to the nucleus during this process. Here we show that conditional loss of PRM...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Kim, Shinseog, Günesdogan, Ufuk, Zylicz, Jan J., Hackett, Jamie A., Cougot, Delphine, Bao, Siqin, Lee, Caroline, Dietmann, Sabine, Allen, George E., Sengupta, Roopsha, Surani, M. Azim
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4250265/
https://ncbi.nlm.nih.gov/pubmed/25457166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.10.003
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