The epigenetic pioneer EGR2 initiates DNA demethylation in differentiating monocytes at both stable and transient binding sites

The differentiation of human blood monocytes (MO), the post-mitotic precursors of macrophages (MAC) and dendritic cells (moDC), is accompanied by the active turnover of DNA methylation, but the extent, consequences and mechanisms of DNA methylation changes remain unclear. Here, we profile and compar...

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Publicado en:Nat Commun
Autores principales: Mendes, Karina, Schmidhofer, Sandra, Minderjahn, Julia, Glatz, Dagmar, Kiesewetter, Claudia, Raithel, Johanna, Wimmer, Julia, Gebhard, Claudia, Rehli, Michael
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2021
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7946903/
https://ncbi.nlm.nih.gov/pubmed/33692344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21661-y
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