5-Hydroxymethylcytosine is an essential intermediate of active DNA demethylation processes in primary human monocytes

BACKGROUND: Cytosine methylation is a frequent epigenetic modification restricting the activity of gene regulatory elements. Whereas DNA methylation patterns are generally inherited during replication, both embryonic and somatic differentiation processes require the removal of cytosine methylation a...

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Bibliographic Details
Main Authors: Klug, Maja, Schmidhofer, Sandra, Gebhard, Claudia, Andreesen, Reinhard, Rehli, Michael
Format: Artigo
Language:Inglês
Published: BioMed Central 2013
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4053946/
https://ncbi.nlm.nih.gov/pubmed/23705593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2013-14-5-r46
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