Allosteric Inhibitors of the Eya2 Phosphatase Are Selective and Inhibit Eya2-mediated Cell Migration

Eya proteins are essential co-activators of the Six family of transcription factors and contain a unique tyrosine phosphatase domain belonging to the haloacid dehalogenase family of phosphatases. The phosphatase activity of Eya is important for the transcription of a subset of Six1-target genes, and...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Krueger, Aaron B., Drasin, David J., Lea, Wendy A., Patrick, Aaron N., Patnaik, Samarjit, Backos, Donald S., Matheson, Christopher J., Hu, Xin, Barnaeva, Elena, Holliday, Michael J., Blevins, Melanie A., Robin, Tyler P., Eisenmesser, Elan Z., Ferrer, Marc, Simeonov, Anton, Southall, Noel, Reigan, Philip, Marugan, Juan, Ford, Heide L., Zhao, Rui
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2014
Gaiak:
Molecular Biophysics
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4047403/
https://ncbi.nlm.nih.gov/pubmed/24755226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.566729
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