A SIX1/EYA2 small molecule inhibitor disrupts EMT and metastasis

Metastasis is the major cause of mortality for cancer patients, and dysregulation of developmental signaling pathways can significantly contribute to the metastatic process. The SIX1/EYA transcriptional complex plays a critical role in the development of multiple organs and is typically downregulate...

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Pubblicato in:Cancer Res
Autori principali: Zhou, Hengbo, Blevins, Melanie A., Hsu, Jessica Y., Kong, Deguang, Galbraith, Matthew D., Goodspeed, Andrew, Culp-Hill, Rachel, Oliphant, Michael UJ., Ramirez, Dominique, Zhang, Lingdi, Pineiro, Jennyvette T., Griner, Lesley Mathews, King, Rebecca, Barnaeva, Elena, Hu, Xin, Southall, Noel T., Ferrer, Marc, Gustafson, Daniel L., Regan, Daniel P., D’Alessandro, Angelo, Costello, James C., Patnaik, Samarjit, Marugan, Juan, Zhao, Rui, Ford, Heide L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7510951/
https://ncbi.nlm.nih.gov/pubmed/32341035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-20-0435
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