Structural and functional analyses of an allosteric Eya2 phosphatase inhibitor that has on target effects in human lung cancer cells

Eya proteins (EYA1–4) are critical developmental transcriptional cofactors that contain an Eya domain (ED) harboring Tyr phosphatase activity. Eya proteins are largely downregulated post-embryogenesis but are re-expressed in cancers, and their Tyr phosphatase activity plays an important role in the...

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Publicado no:Mol Cancer Ther
Main Authors: Anantharajan, Jothi, Zhou, Hengbo, Zhang, Lingdi, Hotz, Taylor, Vincent, Melanie Y., Blevins, Melanie A., Jansson, Anna E., Liang Kuan, John Wee, Ng, Elizabeth Yihui, Yeo, Yee Khoon, Baburajendran, Nithya, Lin, Grace, Hung, Alvin W., Joy, Joma, Patnaik, Samarjit, Marugan, Juan, Rudra, Pratyaydipta, Ghosh, Debashis, Hill, Jeffrey, Keller, Thomas H., Zhao, Rui, Ford, Heide L., Kang, CongBao
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6726557/
https://ncbi.nlm.nih.gov/pubmed/31285279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-18-1239
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