Eya3 promotes breast tumor–associated immune suppression via threonine phosphatase–mediated PD-L1 upregulation

Eya proteins are critical developmental regulators that are highly expressed in embryogenesis but downregulated after development. Amplification and/or re-expression of Eyas occurs in many tumor types. In breast cancer, Eyas regulate tumor progression by acting as transcriptional cofactors and tyros...

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Dettagli Bibliografici
Pubblicato in:J Clin Invest
Autori principali: Vartuli, Rebecca L., Zhou, Hengbo, Zhang, Lingdi, Powers, Rani K., Klarquist, Jared, Rudra, Pratyaydipta, Vincent, Melanie Y., Ghosh, Debashis, Costello, James C., Kedl, Ross M., Slansky, Jill E., Zhao, Rui, Ford, Heide L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2018
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5983346/
https://ncbi.nlm.nih.gov/pubmed/29757193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI96784
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