Eya3 promotes breast tumor–associated immune suppression via threonine phosphatase–mediated PD-L1 upregulation

Eya proteins are critical developmental regulators that are highly expressed in embryogenesis but downregulated after development. Amplification and/or re-expression of Eyas occurs in many tumor types. In breast cancer, Eyas regulate tumor progression by acting as transcriptional cofactors and tyros...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Vartuli, Rebecca L., Zhou, Hengbo, Zhang, Lingdi, Powers, Rani K., Klarquist, Jared, Rudra, Pratyaydipta, Vincent, Melanie Y., Ghosh, Debashis, Costello, James C., Kedl, Ross M., Slansky, Jill E., Zhao, Rui, Ford, Heide L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5983346/
https://ncbi.nlm.nih.gov/pubmed/29757193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI96784
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