Allosteric Inhibitors of the Eya2 Phosphatase Are Selective and Inhibit Eya2-mediated Cell Migration

Eya proteins are essential co-activators of the Six family of transcription factors and contain a unique tyrosine phosphatase domain belonging to the haloacid dehalogenase family of phosphatases. The phosphatase activity of Eya is important for the transcription of a subset of Six1-target genes, and...

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Auteurs principaux: Krueger, Aaron B., Drasin, David J., Lea, Wendy A., Patrick, Aaron N., Patnaik, Samarjit, Backos, Donald S., Matheson, Christopher J., Hu, Xin, Barnaeva, Elena, Holliday, Michael J., Blevins, Melanie A., Robin, Tyler P., Eisenmesser, Elan Z., Ferrer, Marc, Simeonov, Anton, Southall, Noel, Reigan, Philip, Marugan, Juan, Ford, Heide L., Zhao, Rui
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2014
Sujets:
Molecular Biophysics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4047403/
https://ncbi.nlm.nih.gov/pubmed/24755226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.566729
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