טוען...
Identification of 4-phenylquinolin-2(1H)-one as a specific allosteric inhibitor of Akt
Akt plays a major role in tumorigenesis and the development of specific Akt inhibitors as effective cancer therapeutics has been challenging. Here, we report the identification of a highly specific allosteric inhibitor of Akt through a FRET-based high-throughput screening, and characterization of it...
שמור ב:
| הוצא לאור ב: | Sci Rep |
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| Main Authors: | , , , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Nature Publishing Group UK
2017
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5601486/ https://ncbi.nlm.nih.gov/pubmed/28916818 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11870-1 |
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