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Amides are excellent mimics of phosphate internucleoside linkages and are well tolerated in short interfering RNAs
RNA interference (RNAi) has become an important tool in functional genomics and has an intriguing therapeutic potential. However, the current design of short interfering RNAs (siRNAs) is not optimal for in vivo applications. Non-ionic phosphate backbone modifications may have the potential to improv...
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| Autores principales: | , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Oxford University Press
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4041415/ https://ncbi.nlm.nih.gov/pubmed/24813446 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku235 |
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