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Synthesis, Biophysical Studies and RNA Interference Activity of RNA Having Three Consecutive Amide Linkages

RNA sequences having up to three consecutive internal amide linkages were synthesized and studied using UV and NMR spectroscopy. The amide modifications did not interfere with normal base-pairing and A-type RNA conformation. Three consecutive amides were well tolerated in the passenger strand of siR...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Tanui, Paul, Kennedy, Scott D., Lunstad, Benjamin D., Haas, Amanda, Leake, Devin, Rozners, Eriks
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2014
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3970907/
https://ncbi.nlm.nih.gov/pubmed/24435630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3ob42532k
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