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Synthesis, Biophysical Studies and RNA Interference Activity of RNA Having Three Consecutive Amide Linkages

RNA sequences having up to three consecutive internal amide linkages were synthesized and studied using UV and NMR spectroscopy. The amide modifications did not interfere with normal base-pairing and A-type RNA conformation. Three consecutive amides were well tolerated in the passenger strand of siR...

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Détails bibliographiques
Auteurs principaux: Tanui, Paul, Kennedy, Scott D., Lunstad, Benjamin D., Haas, Amanda, Leake, Devin, Rozners, Eriks
Format: Artigo
Langue:Inglês
Publié: 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3970907/
https://ncbi.nlm.nih.gov/pubmed/24435630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3ob42532k
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