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Synthesis and Biological Activity of Short Interfering RNAs Having Several Consecutive Amide Internucleoside Linkages

The success of RNA interference (RNAi) as a research tool and potential therapeutic approach has reinvigorated interest in chemical modifications of RNA. Replacement of the negatively charged phosphates with neutral amides may be expected to improve bioavailability and cellular uptake of small inter...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Chemistry
Egile Nagusiak: Kotikam, Venubabu, Viel, Julien A., Rozners, Eriks
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2019
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6980941/
https://ncbi.nlm.nih.gov/pubmed/31693228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201903754
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