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Synthesis and Biological Activity of Short Interfering RNAs Having Several Consecutive Amide Internucleoside Linkages
The success of RNA interference (RNAi) as a research tool and potential therapeutic approach has reinvigorated interest in chemical modifications of RNA. Replacement of the negatively charged phosphates with neutral amides may be expected to improve bioavailability and cellular uptake of small inter...
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| Published in: | Chemistry |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2019
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6980941/ https://ncbi.nlm.nih.gov/pubmed/31693228 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201903754 |
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