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Synthesis and Biological Activity of Short Interfering RNAs Having Several Consecutive Amide Internucleoside Linkages

The success of RNA interference (RNAi) as a research tool and potential therapeutic approach has reinvigorated interest in chemical modifications of RNA. Replacement of the negatively charged phosphates with neutral amides may be expected to improve bioavailability and cellular uptake of small inter...

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Bibliografiske detaljer
Udgivet i:Chemistry
Main Authors: Kotikam, Venubabu, Viel, Julien A., Rozners, Eriks
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6980941/
https://ncbi.nlm.nih.gov/pubmed/31693228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201903754
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