Amide linkages mimic phosphates in RNA interactions with proteins and are well tolerated in the guide strand of short interfering RNAs

While the use of RNA interference (RNAi) in molecular biology and functional genomics is a well-established technology, in vivo applications of synthetic short interfering RNAs (siRNAs) require chemical modifications. We recently found that amides as non-ionic replacements for phosphodiesters may be...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Mutisya, Daniel, Hardcastle, Travis, Cheruiyot, Samwel K., Pallan, Pradeep S., Kennedy, Scott D., Egli, Martin, Kelley, Melissa L., Smith, Anja van Brabant, Rozners, Eriks
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Chemical Biology and Nucleic Acid Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5737567/
https://ncbi.nlm.nih.gov/pubmed/28854734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx558
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