Amide linkages mimic phosphates in RNA interactions with proteins and are well tolerated in the guide strand of short interfering RNAs

While the use of RNA interference (RNAi) in molecular biology and functional genomics is a well-established technology, in vivo applications of synthetic short interfering RNAs (siRNAs) require chemical modifications. We recently found that amides as non-ionic replacements for phosphodiesters may be...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Mutisya, Daniel, Hardcastle, Travis, Cheruiyot, Samwel K., Pallan, Pradeep S., Kennedy, Scott D., Egli, Martin, Kelley, Melissa L., Smith, Anja van Brabant, Rozners, Eriks
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2017
Témata:
Chemical Biology and Nucleic Acid Chemistry
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5737567/
https://ncbi.nlm.nih.gov/pubmed/28854734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx558
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