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Synthesis, Biophysical Studies and RNA Interference Activity of RNA Having Three Consecutive Amide Linkages
RNA sequences having up to three consecutive internal amide linkages were synthesized and studied using UV and NMR spectroscopy. The amide modifications did not interfere with normal base-pairing and A-type RNA conformation. Three consecutive amides were well tolerated in the passenger strand of siR...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3970907/ https://ncbi.nlm.nih.gov/pubmed/24435630 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3ob42532k |
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