Amides are excellent mimics of phosphate internucleoside linkages and are well tolerated in short interfering RNAs

RNA interference (RNAi) has become an important tool in functional genomics and has an intriguing therapeutic potential. However, the current design of short interfering RNAs (siRNAs) is not optimal for in vivo applications. Non-ionic phosphate backbone modifications may have the potential to improv...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Mutisya, Daniel, Selvam, Chelliah, Lunstad, Benjamin D., Pallan, Pradeep S., Haas, Amanda, Leake, Devin, Egli, Martin, Rozners, Eriks
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2014
Témata:
RNA
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4041415/
https://ncbi.nlm.nih.gov/pubmed/24813446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku235
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky