Propagation of tau pathology in Alzheimer’s disease: identification of novel therapeutic targets

Accumulation and aggregation of the microtubule-associated protein tau are a pathological hallmark of neurodegenerative disorders such as Alzheimer’s disease (AD). In AD, tau becomes abnormally phosphorylated and forms inclusions throughout the brain, starting in the entorhinal cortex and progressiv...

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Hlavní autoři: Pooler, Amy M, Polydoro, Manuela, Wegmann, Susanne, Nicholls, Samantha B, Spires-Jones, Tara L, Hyman, Bradley T
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2013
Témata:
Review
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3978816/
https://ncbi.nlm.nih.gov/pubmed/24152385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/alzrt214
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