PTEN Loss Does Not Predict for Response to RAD001 (Everolimus) in a Glioblastoma Orthotopic Xenograft Test Panel

PURPOSE: Hyperactivation of the phosphatidylinositol 3-kinase/Akt signaling through disruption of PTEN function is common in glioblastoma multiforme, and these genetic changes are predicted to enhance sensitivity to mammalian target of rapamycin (mTOR) inhibitors such as RAD001 (everolimus). EXPERIM...

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Autors principals: Yang, Lin, Clarke, Michelle J., Carlson, Brett L., Mladek, Ann C., Schroeder, Mark A., Decker, Paul, Wu, Wenting, Kitange, Gaspar J., Grogan, Patrick T., Goble, Jennie M., Uhm, Joon, Galanis, Evanthia, Giannini, Caterina, Lane, Heidi A., James, C. David, Sarkaria, Jann N.
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3972037/
https://ncbi.nlm.nih.gov/pubmed/18559622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-07-4152
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