PTEN Loss Does Not Predict for Response to RAD001 (Everolimus) in a Glioblastoma Orthotopic Xenograft Test Panel

PURPOSE: Hyperactivation of the phosphatidylinositol 3-kinase/Akt signaling through disruption of PTEN function is common in glioblastoma multiforme, and these genetic changes are predicted to enhance sensitivity to mammalian target of rapamycin (mTOR) inhibitors such as RAD001 (everolimus). EXPERIM...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Yang, Lin, Clarke, Michelle J., Carlson, Brett L., Mladek, Ann C., Schroeder, Mark A., Decker, Paul, Wu, Wenting, Kitange, Gaspar J., Grogan, Patrick T., Goble, Jennie M., Uhm, Joon, Galanis, Evanthia, Giannini, Caterina, Lane, Heidi A., James, C. David, Sarkaria, Jann N.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3972037/
https://ncbi.nlm.nih.gov/pubmed/18559622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-07-4152
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker