PTEN Loss Does Not Predict for Response to RAD001 (Everolimus) in a Glioblastoma Orthotopic Xenograft Test Panel

PURPOSE: Hyperactivation of the phosphatidylinositol 3-kinase/Akt signaling through disruption of PTEN function is common in glioblastoma multiforme, and these genetic changes are predicted to enhance sensitivity to mammalian target of rapamycin (mTOR) inhibitors such as RAD001 (everolimus). EXPERIM...

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Main Authors: Yang, Lin, Clarke, Michelle J., Carlson, Brett L., Mladek, Ann C., Schroeder, Mark A., Decker, Paul, Wu, Wenting, Kitange, Gaspar J., Grogan, Patrick T., Goble, Jennie M., Uhm, Joon, Galanis, Evanthia, Giannini, Caterina, Lane, Heidi A., James, C. David, Sarkaria, Jann N.
格式: Artigo
語言:Inglês
出版: 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3972037/
https://ncbi.nlm.nih.gov/pubmed/18559622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-07-4152
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