Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange

Aberrant activation of the small GTPase Ras by oncogenic mutation or constitutively active upstream receptor tyrosine kinases results in the deregulation of cellular signals governing growth and survival in ∼30% of all human cancers. However, the discovery of potent inhibitors of Ras has been diffic...

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Autors principals: Burns, Michael C., Sun, Qi, Daniels, R. Nathan, Camper, DeMarco, Kennedy, J. Phillip, Phan, Jason, Olejniczak, Edward T., Lee, Taekyu, Waterson, Alex G., Rossanese, Olivia W., Fesik, Stephen W.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2014
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3948241/
https://ncbi.nlm.nih.gov/pubmed/24550516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1315798111
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