Purification, crystallization and preliminary crystallographic analysis of the catalytic core of cystathionine β-synthase from Saccharomyces cerevisiae

Cystathionine β-synthase (CBS; EC 4.2.1.22) catalyzes the condensation of homocysteine and serine to form cystathionine, with the release of water. In humans, deficiency in CBS activity is the most common cause of hyperhomocysteinaemia and homocystinuria. More than 160 pathogenic mutations in the hu...

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Detaylı Bibliyografya
Asıl Yazarlar: Ereño-Orbea, June, Majtan, Tomas, Oyenarte, Iker, Kraus, Jan P., Martínez-Cruz, Luis Alfonso
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: International Union of Crystallography 2014
Konular:
Crystallization Communications
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3944693/
https://ncbi.nlm.nih.gov/pubmed/24598918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X14001502
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