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Structural insight into the molecular mechanism of allosteric activation of human cystathionine β-synthase by S-adenosylmethionine
Cystathionine β-synthase (CBS) is a heme-dependent and pyridoxal-5′-phosphate–dependent protein that controls the flux of sulfur from methionine to cysteine, a precursor of glutathione, taurine, and H(2)S. Deficiency of CBS activity causes homocystinuria, the most frequent disorder of sulfur amino a...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4169959/ https://ncbi.nlm.nih.gov/pubmed/25197074 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1414545111 |
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