Structural insight into the molecular mechanism of allosteric activation of human cystathionine β-synthase by S-adenosylmethionine

Cystathionine β-synthase (CBS) is a heme-dependent and pyridoxal-5′-phosphate–dependent protein that controls the flux of sulfur from methionine to cysteine, a precursor of glutathione, taurine, and H(2)S. Deficiency of CBS activity causes homocystinuria, the most frequent disorder of sulfur amino a...

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Bibliographic Details
Main Authors: Ereño-Orbea, June, Majtan, Tomas, Oyenarte, Iker, Kraus, Jan P., Martínez-Cruz, Luis Alfonso
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2014
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4169959/
https://ncbi.nlm.nih.gov/pubmed/25197074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1414545111
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