Purification, crystallization and preliminary crystallographic analysis of the catalytic core of cystathionine β-synthase from Saccharomyces cerevisiae

Cystathionine β-synthase (CBS; EC 4.2.1.22) catalyzes the condensation of homocysteine and serine to form cystathionine, with the release of water. In humans, deficiency in CBS activity is the most common cause of hyperhomocysteinaemia and homocystinuria. More than 160 pathogenic mutations in the hu...

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Autori principali: Ereño-Orbea, June, Majtan, Tomas, Oyenarte, Iker, Kraus, Jan P., Martínez-Cruz, Luis Alfonso
Natura: Artigo
Lingua:Inglês
Pubblicazione: International Union of Crystallography 2014
Soggetti:
Crystallization Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3944693/
https://ncbi.nlm.nih.gov/pubmed/24598918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X14001502
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