Tyr-phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate pyruvate dehydrogenase complex

Mitochondrial pyruvate dehydrogenase complex (PDC) is crucial for glucose homoeostasis in mammalian cells. The current understanding of PDC regulation involves inhibitory serine phosphorylation of pyruvate dehydrogenase (PDH) by PDH kinase (PDK), whereas dephosphorylation of PDH by PDH phosphatase (...

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محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Fan, Jun, Shan, Changliang, Kang, Hee-Bum, Elf, Shannon, Xie, Jianxin, Tucker, Meghan, Gu, Ting-Lei, Aguiar, Mike, Lonning, Scott, Chen, Huaibin, Mohammadi, Moosa, Britton, Laura-Mae P., Garcia, Benjamin A., Aleckovic, Masa, Kang, Yibin, Kaluz, Stefan, Devi, Narra, Van Meir, Erwin, Hitosugi, Taro, Seo, Jae Ho, Lonial, Sagar, Gaddh, Manila, Arellano, Martha, Khoury, Hanna J., Khuri, Fadlo R., Boggon, Titus J., Kang, Sumin, Chen, Jing
التنسيق: Artigo
اللغة:Inglês
منشور في: 2014
الموضوعات:
Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC3943932/
https://ncbi.nlm.nih.gov/pubmed/24486017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.12.026
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