Tyr-94 Phosphorylation Inhibits Pyruvate Dehydrogenase Phosphatase 1 and Promotes Tumor Growth

Many cancer cells rely more on aerobic glycolysis (the Warburg effect) than mitochondrial oxidative phosphorylation and catabolize glucose at a high rate. Such a metabolic switch is suggested to be due in part to functional attenuation of mitochondria in cancer cells. However, how oncogenic signals...

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Detalhes bibliográficos
Main Authors: Shan, Changliang, Kang, Hee-Bum, Elf, Shannon, Xie, Jianxin, Gu, Ting-Lei, Aguiar, Mike, Lonning, Scott, Hitosugi, Taro, Chung, Tae-Wook, Arellano, Martha, Khoury, Hanna J., Shin, Dong M., Khuri, Fadlo R., Boggon, Titus J., Fan, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4118105/
https://ncbi.nlm.nih.gov/pubmed/24962578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.581124
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