Tyr-phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate pyruvate dehydrogenase complex

Mitochondrial pyruvate dehydrogenase complex (PDC) is crucial for glucose homoeostasis in mammalian cells. The current understanding of PDC regulation involves inhibitory serine phosphorylation of pyruvate dehydrogenase (PDH) by PDH kinase (PDK), whereas dephosphorylation of PDH by PDH phosphatase (...

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Autors principals: Fan, Jun, Shan, Changliang, Kang, Hee-Bum, Elf, Shannon, Xie, Jianxin, Tucker, Meghan, Gu, Ting-Lei, Aguiar, Mike, Lonning, Scott, Chen, Huaibin, Mohammadi, Moosa, Britton, Laura-Mae P., Garcia, Benjamin A., Aleckovic, Masa, Kang, Yibin, Kaluz, Stefan, Devi, Narra, Van Meir, Erwin, Hitosugi, Taro, Seo, Jae Ho, Lonial, Sagar, Gaddh, Manila, Arellano, Martha, Khoury, Hanna J., Khuri, Fadlo R., Boggon, Titus J., Kang, Sumin, Chen, Jing
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3943932/
https://ncbi.nlm.nih.gov/pubmed/24486017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.12.026
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