Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation

How oncogenic signalling coordinates glycolysis and anabolic biosynthesis in cancer cells remains unclear. We recently reported that the glycolytic enzyme phosphoglycerate mutase 1 (PGAM1) regulates anabolic biosynthesis by controlling intracellular levels of its substrate 3-phosphoglycerate (3-PG)...

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Main Authors: Hitosugi, Taro, Zhou, Lu, Fan, Jun, Elf, Shannon, Zhang, Liang, Xie, Jianxin, Wang, Yi, Gu, Ting-Lei, Aleckovic, Masa, LeRoy, Gary, Kang, Yibin, Kang, Hee-Bum, Seo, Jae-Ho, Shan, Changliang, Jin, Peng, Gong, Weimin, Lonial, Sagar, Arellano, Martha L., Khoury, Hanna J., Chen, Georgia Z., Shin, Dong M., Khuri, Fadlo R., Boggon, Titus J., Kang, Sumin, He, Chuan, Chen, Jing
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2013
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3648882/
https://ncbi.nlm.nih.gov/pubmed/23653202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2759
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