Tyr-301 Phosphorylation Inhibits Pyruvate Dehydrogenase by Blocking Substrate Binding and Promotes the Warburg Effect

The mitochondrial pyruvate dehydrogenase complex (PDC) plays a crucial role in regulation of glucose homoeostasis in mammalian cells. PDC flux depends on catalytic activity of the most important enzyme component pyruvate dehydrogenase (PDH). PDH kinase inactivates PDC by phosphorylating PDH at speci...

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Main Authors: Fan, Jun, Kang, Hee-Bum, Shan, Changliang, Elf, Shannon, Lin, Ruiting, Xie, Jianxin, Gu, Ting-Lei, Aguiar, Mike, Lonning, Scott, Chung, Tae-Wook, Arellano, Martha, Khoury, Hanna J., Shin, Dong M., Khuri, Fadlo R., Boggon, Titus J., Kang, Sumin, Chen, Jing
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2014
主題:
Metabolism
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176253/
https://ncbi.nlm.nih.gov/pubmed/25104357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.593970
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