Tyrosine Phosphorylation of Lactate Dehydrogenase A Is Important for NADH/NAD(+) Redox Homeostasis in Cancer Cells

The Warburg effect describes an increase in aerobic glycolysis and enhanced lactate production in cancer cells. Lactate dehydrogenase A (LDH-A) regulates the last step of glycolysis that generates lactate and permits the regeneration of NAD(+). LDH-A gene expression is believed to be upregulated by...

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Hauptverfasser: Fan, Jun, Hitosugi, Taro, Chung, Tae-Wook, Xie, Jianxin, Ge, Qingyuan, Gu, Ting-Lei, Polakiewicz, Roberto D., Chen, Georgia Z., Boggon, Titus J., Lonial, Sagar, Khuri, Fadlo R., Kang, Sumin, Chen, Jing
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2011
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3233034/
https://ncbi.nlm.nih.gov/pubmed/21969607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.06120-11
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