Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth

The Warburg effect describes a pro-oncogenic metabolism switch such that cancer cells take up more glucose than normal tissue and favor incomplete oxidation of glucose even in the presence of oxygen. To better understand how tyrosine kinase signaling, which is commonly increased in tumors, regulates...

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Main Authors: Hitosugi, Taro, Kang, Sumin, Vander Heiden, Matthew G., Chung, Tae-Wook, Elf, Shannon, Lythgoe, Katherine, Dong, Shaozhong, Lonial, Sagar, Wang, Xu, Chen, Georgia Z., Xie, Jianxin, Gu, Ting-Lei, Polakiewicz, Roberto D., Roesel, Johannes L., Boggon, Titus J., Khuri, Fadlo R., Gilliland, D. Gary, Cantley, Lewis C., Kaufman, Jonathan, Chen, Jing
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812789/
https://ncbi.nlm.nih.gov/pubmed/19920251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2000431
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