Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth

The Warburg effect describes a pro-oncogenic metabolism switch such that cancer cells take up more glucose than normal tissue and favor incomplete oxidation of glucose even in the presence of oxygen. To better understand how tyrosine kinase signaling, which is commonly increased in tumors, regulates...

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Bibliografische gegevens
Hoofdauteurs: Hitosugi, Taro, Kang, Sumin, Vander Heiden, Matthew G., Chung, Tae-Wook, Elf, Shannon, Lythgoe, Katherine, Dong, Shaozhong, Lonial, Sagar, Wang, Xu, Chen, Georgia Z., Xie, Jianxin, Gu, Ting-Lei, Polakiewicz, Roberto D., Roesel, Johannes L., Boggon, Titus J., Khuri, Fadlo R., Gilliland, D. Gary, Cantley, Lewis C., Kaufman, Jonathan, Chen, Jing
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2009
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812789/
https://ncbi.nlm.nih.gov/pubmed/19920251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2000431
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