Fibroblast Growth Factor Receptor 3 Associates with and Tyrosine Phosphorylates p90 RSK2, Leading to RSK2 Activation That Mediates Hematopoietic Transformation

Dysregulation of the receptor tyrosine kinase fibroblast growth factor receptor 3 (FGFR3) plays a pathogenic role in a number of human hematopoietic malignancies and solid tumors. These include t(4;14) multiple myeloma associated with ectopic expression of FGFR3 and t(4;12)(p16;p13) acute myeloid le...

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Hauptverfasser: Kang, Sumin, Elf, Shannon, Dong, Shaozhong, Hitosugi, Taro, Lythgoe, Katherine, Guo, Ailan, Ruan, Hong, Lonial, Sagar, Khoury, Hanna J., Williams, Ifor R., Lee, Benjamin H., Roesel, Johannes L., Karsenty, Gerard, Hanauer, André, Taunton, Jack, Boggon, Titus J., Gu, Ting-Lei, Chen, Jing
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2009
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2663316/
https://ncbi.nlm.nih.gov/pubmed/19223461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00998-08
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