FGFR3 Activates RSK2 to Mediate Hematopoietic Transformation through Tyrosine Phosphorylation of RSK2 and Activation of the MEK/ERK Pathway

To better understand the signaling properties of oncogenic FGFR3, we performed phospho-proteomics studies to identify potential downstream signaling effectors that are tyrosine phosphorylated in hematopoietic cells expressing constitutively activated leukemogenic FGFR3 mutants. We found that FGFR3 d...

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Bibliografiset tiedot
Päätekijät: Kang, Sumin, Dong, Shaozhong, Gu, Ting-Lei, Guo, Ailan, Cohen, Michael S., Lonial, Sagar, Khoury, Hanna Jean, Fabbro, Doriano, Gary Gilliland, D., Leif Bergsagel, P., Taunton, Jack, Polakiewicz, Roberto D., Chen, Jing
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2007
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2424114/
https://ncbi.nlm.nih.gov/pubmed/17785202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2007.08.003
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