Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation

How oncogenic signalling coordinates glycolysis and anabolic biosynthesis in cancer cells remains unclear. We recently reported that the glycolytic enzyme phosphoglycerate mutase 1 (PGAM1) regulates anabolic biosynthesis by controlling intracellular levels of its substrate 3-phosphoglycerate (3-PG)...

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Autors principals: Hitosugi, Taro, Zhou, Lu, Fan, Jun, Elf, Shannon, Zhang, Liang, Xie, Jianxin, Wang, Yi, Gu, Ting-Lei, Aleckovic, Masa, LeRoy, Gary, Kang, Yibin, Kang, Hee-Bum, Seo, Jae-Ho, Shan, Changliang, Jin, Peng, Gong, Weimin, Lonial, Sagar, Arellano, Martha L., Khoury, Hanna J., Chen, Georgia Z., Shin, Dong M., Khuri, Fadlo R., Boggon, Titus J., Kang, Sumin, He, Chuan, Chen, Jing
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3648882/
https://ncbi.nlm.nih.gov/pubmed/23653202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2759
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