Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth

It remains unclear how cancer cells coordinate glycolysis and biosynthesis to support rapidly growing tumors. We found that glycolytic enzyme phosphoglycerate mutase 1 (PGAM1), commonly upregulated in human cancers due to loss of TP53, contributes to biosynthesis regulation in part by controlling in...

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Detalhes bibliográficos
Main Authors: Hitosugi, Taro, Zhou, Lu, Elf, Shannon, Fan, Jun, Kang, Hee-Bum, Seo, Jae Ho, Shan, Changliang, Dai, Qing, Zhang, Liang, Xie, Jianxin, Gu, Ting-Lei, Jin, Peng, Aleckovic, Masa, LeRoy, Gary, Kang, Yibin, Sudderth, Jessica A., DeBerardinis, Ralph J., Luan, Chi-Hao, Chen, Georgia Z., Muller, Susan, Shin, Dong M., Owonikoko, Taofeek K., Lonial, Sagar, Arellano, Martha L., Khoury, Hanna J., Khuri, Fadlo R., Lee, Benjamin H., Ye, Keqiang, Boggon, Titus J., Kang, Sumin, He, Chuan, Chen, Jing
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3500524/
https://ncbi.nlm.nih.gov/pubmed/23153533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2012.09.020
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