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Targeting the PI3K/AKT/mTOR Pathway: Biomarkers of Success and Tribulation

PI3K/AKT/mTOR pathway is an established oncogenic driver in humans. Targeted biologic agents against components of this pathway have shown promising activity leading to the approval of the allosteric inhibitors of mTOR, everolimus, and temsirolimus for the treatment of advanced cancers of the kidney...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Owonikoko, Taofeek K., Khuri, Fadlo R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3821994/
https://ncbi.nlm.nih.gov/pubmed/23714559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/EdBook_AM.2013.33.e395
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