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Targeting the PI3K/AKT/mTOR Pathway: Biomarkers of Success and Tribulation
PI3K/AKT/mTOR pathway is an established oncogenic driver in humans. Targeted biologic agents against components of this pathway have shown promising activity leading to the approval of the allosteric inhibitors of mTOR, everolimus, and temsirolimus for the treatment of advanced cancers of the kidney...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3821994/ https://ncbi.nlm.nih.gov/pubmed/23714559 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/EdBook_AM.2013.33.e395 |
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