Circumvention of Mcl-1-Dependent Drug Resistance by Simultaneous Chk1 and MEK1/2 Inhibition in Human Multiple Myeloma Cells

The anti-apoptotic protein Mcl-1 plays a major role in multiple myeloma (MM) cell survival as well as bortezomib- and microenvironmental forms of drug resistance in this disease. Consequently, there is a critical need for strategies capable of targeting Mcl-1-dependent drug resistance in MM. The pre...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Pei, Xin-Yan, Dai, Yun, Felthousen, Jessica, Chen, Shuang, Takabatake, Yukie, Zhou, Liang, Youssefian, Leena E., Sanderson, Michael W., Bodie, Wesley W., Kramer, Lora B., Orlowski, Robert Z., Grant, Steven
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2014
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3942309/
https://ncbi.nlm.nih.gov/pubmed/24594907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0089064
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