Interruption of the Ras/MEK/ERK signaling cascade enhances Chk1 inhibitor–induced DNA damage in vitro and in vivo in human multiple myeloma cells

The role of the Ras/MEK/ERK pathway was examined in relation to DNA damage in human multiple myeloma (MM) cells exposed to Chk1 inhibitors in vitro and in vivo. Exposure of various MM cells to marginally toxic concentrations of the Chk1 inhibitors UCN-01 or Chk1i modestly induced DNA damage, accompa...

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Detalhes bibliográficos
Main Authors: Dai, Yun, Chen, Shuang, Pei, Xin-Yan, Almenara, Jorge A., Kramer, Lora B., Venditti, Charis A., Dent, Paul, Grant, Steven
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2008
Assuntos:
Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2532812/
https://ncbi.nlm.nih.gov/pubmed/18614762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-05-159392
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