Interruption of the Ras/MEK/ERK signaling cascade enhances Chk1 inhibitor–induced DNA damage in vitro and in vivo in human multiple myeloma cells

The role of the Ras/MEK/ERK pathway was examined in relation to DNA damage in human multiple myeloma (MM) cells exposed to Chk1 inhibitors in vitro and in vivo. Exposure of various MM cells to marginally toxic concentrations of the Chk1 inhibitors UCN-01 or Chk1i modestly induced DNA damage, accompa...

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Detaylı Bibliyografya
Asıl Yazarlar: Dai, Yun, Chen, Shuang, Pei, Xin-Yan, Almenara, Jorge A., Kramer, Lora B., Venditti, Charis A., Dent, Paul, Grant, Steven
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Hematology 2008
Konular:
Neoplasia
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2532812/
https://ncbi.nlm.nih.gov/pubmed/18614762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-05-159392
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