Cytokinetically quiescent (G(0)/G(1)) human multiple myeloma cells are susceptible to simultaneous inhibition of Chk1 and MEK1/2

Effects of Chk1 and MEK1/2 inhibition were investigated in cytokinetically quiescent multiple myeloma (MM) and primary CD138(+) cells. Coexposure to the Chk1 and MEK1/2 inhibitors AZD7762 and selumetinib (AZD6244) robustly induced apoptosis in various MM cells and CD138(+) primary samples, but spare...

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Bibliographische Detailangaben
Hauptverfasser: Pei, Xin-Yan, Dai, Yun, Youssefian, Leena E., Chen, Shuang, Bodie, Wesley W., Takabatake, Yukie, Felthousen, Jessica, Almenara, Jorge A., Kramer, Lora B., Dent, Paul, Grant, Steven
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2011
Schlagworte:
Lymphoid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3217403/
https://ncbi.nlm.nih.gov/pubmed/21911831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-02-339432
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