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Cytokinetically quiescent (G(0)/G(1)) human multiple myeloma cells are susceptible to simultaneous inhibition of Chk1 and MEK1/2
Effects of Chk1 and MEK1/2 inhibition were investigated in cytokinetically quiescent multiple myeloma (MM) and primary CD138(+) cells. Coexposure to the Chk1 and MEK1/2 inhibitors AZD7762 and selumetinib (AZD6244) robustly induced apoptosis in various MM cells and CD138(+) primary samples, but spare...
में बचाया:
| मुख्य लेखकों: | , , , , , , , , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
American Society of Hematology
2011
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3217403/ https://ncbi.nlm.nih.gov/pubmed/21911831 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-02-339432 |
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