Circumvention of Mcl-1-Dependent Drug Resistance by Simultaneous Chk1 and MEK1/2 Inhibition in Human Multiple Myeloma Cells

The anti-apoptotic protein Mcl-1 plays a major role in multiple myeloma (MM) cell survival as well as bortezomib- and microenvironmental forms of drug resistance in this disease. Consequently, there is a critical need for strategies capable of targeting Mcl-1-dependent drug resistance in MM. The pre...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Pei, Xin-Yan, Dai, Yun, Felthousen, Jessica, Chen, Shuang, Takabatake, Yukie, Zhou, Liang, Youssefian, Leena E., Sanderson, Michael W., Bodie, Wesley W., Kramer, Lora B., Orlowski, Robert Z., Grant, Steven
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3942309/
https://ncbi.nlm.nih.gov/pubmed/24594907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0089064
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados