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An Essential Role for MCL-1 in ATR-mediated CHK1 Phosphorylation
Here we report a novel role for myeloid cell leukemia 1 (Mcl-1), a Bcl-2 family member, in regulating phosphorylation and activation of DNA damage checkpoint kinase, Chk1. Increased expression of nuclear Mcl-1 and/or a previously reported short nuclear form of Mcl-1, snMcl-1, was observed in respons...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
The American Society for Cell Biology
2008
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2488305/ https://ncbi.nlm.nih.gov/pubmed/18495871 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E07-11-1171 |
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