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ATR-Mediated Checkpoint Pathways Regulate Phosphorylation and Activation of Human Chk1

Chk1 is an evolutionarily conserved protein kinase that regulates cell cycle progression in response to checkpoint activation. In this study, we demonstrated that agents that block DNA replication or cause certain forms of DNA damage induce the phosphorylation of human Chk1. The phosphorylated form...

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Autori principali: Zhao, Hui, Piwnica-Worms, Helen
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2001
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC87074/
https://ncbi.nlm.nih.gov/pubmed/11390642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.13.4129-4139.2001
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