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ATR-Mediated Checkpoint Pathways Regulate Phosphorylation and Activation of Human Chk1

Chk1 is an evolutionarily conserved protein kinase that regulates cell cycle progression in response to checkpoint activation. In this study, we demonstrated that agents that block DNA replication or cause certain forms of DNA damage induce the phosphorylation of human Chk1. The phosphorylated form...

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Detalles Bibliográficos
Main Authors: Zhao, Hui, Piwnica-Worms, Helen
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2001
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC87074/
https://ncbi.nlm.nih.gov/pubmed/11390642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.13.4129-4139.2001
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