ATR(Mec1) Phosphorylation-independent Activation of Chk1 in Vivo

The conserved protein kinase Chk1 is a player in the defense against DNA damage and replication blocks. The current model is that after DNA damage or replication blocks, ATR(Mec1) phosphorylates Chk1 on the non-catalytic C-terminal domain. However, the mechanism of activation of Chk1 and the functio...

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Bibliographic Details
Main Authors: Chen, Yinhuai, Caldwell, Julie M., Pereira, Elizabeth, Baker, Robert W., Sanchez, Yolanda
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2610496/
https://ncbi.nlm.nih.gov/pubmed/18984588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806530200
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